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Shh maintains dermal papilla identity and hair morphogenesis via a Noggin–Shh regulatory loop

Identifieur interne : 003E80 ( Main/Exploration ); précédent : 003E79; suivant : 003E81

Shh maintains dermal papilla identity and hair morphogenesis via a Noggin–Shh regulatory loop

Auteurs : Wei-Meng Woo [États-Unis] ; Hanson H. Zhen [États-Unis] ; Anthony E. Oro [États-Unis]

Source :

Genes & Development [ 0890-9369 ] ; 2012.

RBID : PMC:3371411

Abstract

Recently, studies have shown that many lethal epithelial cancers depend on the tumor-derived Shh ligand acting on the tumor stroma for growth. In this study by Oro and colleagues, the authors investigate the role of dermal-specific Shh signaling in dermal papillae formation and hair growth. During hair follicle morphogenesis, dermal papillae function as signaling centers that regulate morphogenesis; however, the molecular basis of dermal papillae formation is unclear. By using both a conventional Cre-lox genetic model and a new RNAi/hair reconstitution technique, the authors demonstrate that Shh acts on the dermal compartment to maintain its own expression through inducing Noggin. Thus, these findings provide novel insight into the actions of Shh in different cell populations within the same tissue during morphogenesis.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371411

DOI: 10.1101/gad.187401.112
PubMed: 22661232
PubMed Central: 3371411

Affiliations:

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Shh maintains dermal papilla identity and hair morphogenesis via a Noggin–Shh regulatory loop

Shh maintains dermal papilla identity and hair morphogenesis via a Noggin–Shh regulatory loop

Source :

Abstract

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